Fmoc-DL-Nle-OH, with the CAS number 144701-20-2, is a chemical compound commonly used in peptide synthesis. It is a derivative of the amino acid norleucine (Nle) and features a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, which is widely utilized in solid-phase peptide synthesis to protect the amino group during the coupling reactions. The Fmoc group is known for its stability under basic conditions and can be removed under mild acidic conditions, allowing for selective deprotection. This compound is typically a white to off-white solid and is soluble in organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO), but less soluble in water. Its structure includes both hydrophobic and polar characteristics, making it suitable for various biochemical applications. Fmoc-DL-Nle-OH is particularly valuable in the synthesis of peptides that require specific modifications or in the development of peptide-based drugs. Proper handling and storage are essential due to its potential reactivity and the need for maintaining its integrity during synthesis processes.

Fmoc-DL-Nle-OH

Fmoc-DL-norleucine is a fluorophore that can be used to measure the uptake of drugs by cells in culture. It has been shown to bind to the antigen, which is then measured using fluorescence spectroscopy. The linker is an amino acid that connects the fluorophore with the drug. Immobilized Fmoc-DL-norleucine has been shown to inhibit replication of human immunodeficiency virus (HIV) in k562 cells and can also be used as a congener for silico analysis.

CAS 144701-20-2: Fmoc-DL-Nle-OH

Fmoc-DL-norleucine

Ref: 3D-FF48580

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid

Ref: IN-DA00AOTL

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid

Ref: 54-OR75883