CAS 145370-39-4: 4H-1-Benzopyran-4-one, 2-(3-methoxy-4-nitrophenyl)-

MNF, or 3,4-MNF, blocks AhR, limits UVR immune impact, and boosts Tregs in mouse CHS.

Applications 3’-Methoxy-4’-nitroflavone is a aryl hydrocarbon receptor antagonist that enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism. 3’-Methoxy-4’-nitroflavone differentially altered aryl hydrocarbon also showed receptor activity in mouse and human hepatoma cell. References Zhou, J., Gasiewicz, T.: Arch. Biochem. Biophys., 416, 68 (2003); Smith, K., et al.: J. Pharm. Exp. Ther., 338, 318 (2011);