CAS 146-48-5: yohimbine

Applications 17alpha-Hydroxy-yohimban-16alpha-carboxylic acid methyl ester (cas# 146-48-5) is a useful research chemical.Also, it is an intermediate used in the synthesis of Corynanthine (C696915), which is a alkaloids from root samples of R. serpentina and it possesses cytotoxic activities against human breast cancer cells. References Sagi, S., et al.: Anal. Bioanal. Chem., 408, 177-190 (2016); Cohen, P. A., et al.: Drug Test. Anal., 8, 357-369 (2016); Wang, C., et al.: Chem. Nat. Compd., 49, 1177-1178 (2014)

Yohimbine

Yohimbe bark is a phytotherapeutic agent, derived from the bark of the Pausinystalia johimbe tree, which is an evergreen species native to Central and West Africa. This product acts primarily through its active compound called yohimbine, which functions as an alpha-2 adrenergic receptor antagonist. By blocking these receptors, yohimbine increases the release of norepinephrine, leading to enhanced sympathetic nervous system activity. This pharmacological action results in vasodilation, promoting increased blood flow, particularly to peripheral tissues. Yohimbe bark has been studied for its potential applications in treating erectile dysfunction, enhancing athletic performance, and as a weight loss aid by increasing lipid mobilization. Its effects on enhancing blood flow and energy utilization make it a subject of interest in both the fields of sexual health and sports medicine. However, its use is complex due to side effects such as increased heart rate and anxiety, necessitating careful dosing and monitoring in clinical settings. Research continues into its broader effects, interactions, and potential therapeutic applications.

Yohimbine is a nonselective alpha 2-adrenergic receptor (AR) antagonist(IC50 : 0.6 μM)