Inosine, 2-chloro-2'-deoxy-6-O-methyl- is a modified nucleoside that features a purine base, specifically hypoxanthine, linked to a sugar moiety. This compound is characterized by the presence of a chlorine atom at the 2-position of the deoxyribose sugar and a methoxy group at the 6-position. The modification of the sugar and the halogen substitution can influence its biological activity and stability compared to unmodified nucleosides. Inosine derivatives are often studied for their potential roles in antiviral therapies and as intermediates in nucleic acid synthesis. The presence of the methoxy group may enhance lipophilicity, potentially affecting cellular uptake and interaction with biological targets. As with many nucleoside analogs, the pharmacological properties, including efficacy and toxicity, are of significant interest in medicinal chemistry. The compound's CAS number, 146196-07-8, allows for precise identification in chemical databases and literature.

Inosine, 2-chloro-2'-deoxy-6-O-methyl-

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Applications 2-Chloro-2'-deoxy-6-O-methylinosine is used as a reagent in the preparation of 2-chloro-2'-deoxyadenosine analogs via regioselective and stereoselective glycosylation of 6-(substituted-imidazol-1-yl)purines with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride.
References Zhong, M., et al.: J. Org. Chem., 71, 7773 (2006);


2-Chloro-2'-deoxy-6-O-methylinosine

2-Chloro-2'-deoxy-6-O-methylinosine is a Nucleoside Derivative - Halo-nucleoside, 2-Modified purine nucleoside, 6-Modified purine nucleoside.

CAS 146196-07-8: Inosine, 2-chloro-2'-deoxy-6-O-methyl-

2-Chloro-2'-deoxy-6-O-methylinosine

Ref: TR-C292980

2-Chloro-2'-deoxy-6-O-methylinosine

Ref: TM-TNU1581

Inosine Impurity 1

Ref: 4Z-I-404