CAS 146724-94-9: Diethylamine NONOate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diethylamine is a colorless liquid with a sweet, ether-like odor. It is soluble in water and alcohols. Diethylamine reacts with nitrite to form an adduct that has been shown to be protonated and to have profiles similar to those of nitric oxide. This adduct is cytotoxic and can cause significant blood pressure reduction. The compound type of diethylamine (nitric oxide) adduct is not yet known, but it has been found to have antigenicity that stimulates the inflammatory response.

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity that accelerates healing of MRSA infected wounds.

Detanonoate is a cyclase inhibitor that can induce apoptosis and inhibit the production of pro-inflammatory cytokines. Detanonoate has been shown to be minimally toxic in cell culture studies and to have a minimal effect on enzyme activity. Detanonoate also has significant cytotoxicity against tumor cells, with minimal toxicity against normal cells. It also exerts an anti-inflammatory effect through its inhibition of toll-like receptor 4, which is involved in the inflammatory response. Detanonoate has been shown to decrease tumor growth by inhibiting matrix metalloproteinase-9 (MMP-9) activity, which may be due to its ability to inhibit mitochondrial membrane potential. Detanonoate is used for the treatment of bowel disease.