4-Hydroxy nonenal mercapturic acid is a metabolite derived from the conjugation of 4-hydroxy-2-nonenal (4-HNE), a reactive aldehyde formed during lipid peroxidation, with glutathione. This compound is characterized by its mercapturic acid structure, which typically includes a cysteine-derived moiety that facilitates its excretion from the body. It serves as a biomarker for oxidative stress and lipid peroxidation, indicating cellular damage and potential involvement in various pathological conditions. The presence of this compound in biological samples can provide insights into the extent of oxidative damage and the body's detoxification processes. Its analysis is often performed using advanced techniques such as liquid chromatography coupled with mass spectrometry (LC-MS), allowing for sensitive detection in complex biological matrices. Understanding the levels of 4-hydroxy nonenal mercapturic acid can be crucial in research related to diseases linked to oxidative stress, including neurodegenerative disorders and cancer.

4-HYDROXY NONENAL MERCAPTURIC ACID

146764-24-1: N-Acetyl-S-(Tetrahydro-5-Hydroxy-2-Pentyl-3-Furanyl)-L-Cysteine

Applications 4-Hydroxy Nonenal Mercapturic Acid-d3, is a labeled analogue of 4-Hydroxy Nonenal Mercapturic Acid (H296810), a mercapturic acid conjugate of 4-hydroxy nonenal (4-HNE) formed to clear 4-HNE from plasma via enterohepatic circulation.
References Alary, J., et al., Chemical research in toxicology. 8(1): 34-9. PMID: 7703364;


4-Hydroxy Nonenal Mercapturic Acid-d3

Peroxidation of ω-6 PUFAs produces 4-HNE, which is rapidly cleared and excreted, mostly as urine metabolites, within 48h in rats.

CAS 146764-24-1: 4-HYDROXY NONENAL MERCAPTURIC ACID

4-Hydroxy Nonenal Mercapturic Acid-d3

Ref: TR-H296812

4-hydroxy Nonenal Mercapturic Acid

Ref: TM-T35971

4-Hydroxy Nonenal Mercapturic Acid

Ref: 4Z-A-336001