CAS 146954-74-7: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE

2'-Deoxy-5'-O-DMT-2'-fluorouridine is a medicament that belongs to the group of antineoplastic agents and is used in cancer treatment. It inhibits the synthesis of DNA by inhibiting the enzyme thymidylate synthetase, which is required for the formation of thymine nucleotides. This drug has been shown to be effective against some cancer cells in vitro and in vivo, but not all. 2'-Deoxy-5'-O-DMT-2'-fluorouridine can also inhibit terminal growth phases and induce programmed cell death. Solid phase synthesis has been used to synthesize this molecule as a phosphoramidite.

2'-Deoxy-5'-O-DMT-2'-fluorouridine, derived from 5'-O-DMTr-5-FUDR, displays potent anti-YFV effects.

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5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-uridine