CAS: 1473404-51-1

(E)-4-((3-Chlorophenyl)Diazenyl)-5-Hydroxy-3-(4-Nitrophenyl)-1H-Pyrazole-1-Carbothioamide

Hck-IN-1 selectively inhibits Nef:Hck, IC50: 2.8 μM; >20 μM for Hck alone. Potent HIV-1 Nef antagonist, IC50: 100-300 nM for HIV-1 replication.

Hck-IN-1

HCK-IN-1 is a peptide that was originally isolated from the venom of the black mamba and has been shown to activate potassium ion channels. HCK-IN-1 is an inhibitor of voltage activated sodium and calcium channels, which are important in cardiac excitation. It also has been shown to have anti-inflammatory effects by inhibiting the production of cytokines such as IL-6, TNF-α, and IL-8. HCK-IN-1 has potential applications in cell biology research as it is a high purity, potent activator of potassium ion channels. The peptide can also be used to inhibit voltage activated sodium and calcium channels in cardiac cells.