CAS 14813-01-5: 1-Benzyl-3-hydroxypiperidine

1-Benzylpiperidin-3-ol

1-Benzyl-3-piperidinol is a synthetic chemical that has been used as a long-acting calcium antagonist. It is synthesized by the reaction of 1,2-dibromoethane with piperidine and benzaldehyde in the presence of an acid catalyst. The reaction yield is high, and impurities are low. This drug substance is soluble in organic solvents, such as chloroform, ethyl acetate, and ether. The synthesis process uses chiral catalysts to produce the desired enantiomeric form of the drug substance. The use of immobilized catalysts improves the conversion rate, kinetic parameters, and reaction yield of this process.

Applications N-Benzyl-3-hydroxypiperidine has been used as a reactant in the preparation of optically active azidopiperidines. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Cochi, A., et. al.: Eur. J. Org. Chem., 2012, 2023 (2012)