CAS 148672-09-7: Estrone 3-O-Sulfamate
Formula:C18H23NO4S
InChI:InChI=1/C18H23NO4S/c1-18-9-8-14-13-5-3-12(23-24(19,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16H,2,4,6-9H2,1H3,(H2,19,21,22)/t14-,15-,16+,18+/m1/s1
Synonyms:- 3-((Aminosulfonyl)oxy)estra-1,3,5(10)-trien-17-one
- Emate compound
- Estra-1,3,5(10)-trien-17-one-3-sulfamate
- Oestrone-3-O-sulphamate
- Estra-1,3,5(10)-trien-17-one, 3-((aminosulfonyl)oxy)-
- 17-Oxoestra-1,3,5(10)-Trien-3-Yl Sulfamate
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Found 5 products.
Estrone 3-O-sulfamate
CAS:Estrone 3-O-sulfamate is a sulfamoylating agent that inhibits the enzyme aromatase, which is responsible for converting androgenic hormones to oestrogen. The irreversible inhibition of this enzyme leads to decreased oestrogen levels in the body. Estrone 3-O-sulfamate has been shown to be effective against solid tumours in mice, as well as breast cancer cell lines in vitro. It binds reversibly to the sulfhydryl group of cysteine residues on the enzyme and irreversibly inhibits its activity by forming a covalent bond with the sulfur atom in cysteine. This prevents the formation of an enzyme-substrate complex and prevents synthesis of oestrone from androgenic hormones.Formula:C18H23NO4SPurity:Min. 95%Color and Shape:PowderMolecular weight:349.45 g/molEstrone 3-O-Sulfamate
CAS:Controlled ProductApplications A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase >99% at 0.1uM in intact MCF-7 cells, IC50=65pM. References Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)Formula:C18H23NO4SColor and Shape:NeatMolecular weight:349.44Estrone O-sulfamate
CAS:Estrone 3-O-sulfamate, a strong STS inhibitor with IC50 of 18 nM in placenta and 0.83 nM in MCF-7 cells, is used in cancer research.Formula:C18H23NO4SPurity:99.86%Color and Shape:SolidMolecular weight:349.44Estrone 3-O-Sulfamate
CAS:Formula:C18H23NO4SPurity:97%Color and Shape:SolidMolecular weight:349.44451999999995
