CAS 1489-69-6: Cyclopropanecarboxaldehyde

Cyclopropanecarboxaldehyde reacts with Grignard or organolithium reagents to give the expected secondary alcohols. These are susceptible to ring opening in the presence of HBr, providing stereoselective access to homoallylic bromides. It is also used in the synthesis of eta(2)-enonenickel complexes by reacting with [Ni(cod)(2)] (cod = 1,5-cyclooctadiene) and PBu(3) and to prepare a cyclopropylidene tetralone which underwent an enantioselective palladium-catalyzed [3+2] TMM cycloaddition providing a chiral spiro-fused cyclopentene. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Cyclopropanecarboxaldehyde is a reactive organic compound that is used in the synthesis of other compounds. It has been shown to be a useful intermediate for the synthesis of heterocycles, such as indoles and quinolines. Cyclopropanecarboxaldehyde binds to nitrogen atoms through intermolecular hydrogen bond and has a coordination geometry of square-planar. The presence of two asymmetric carbon atoms allows for an enantioselective synthesis. Cyclopropanecarboxaldehyde has been shown to be effective against human immunodeficiency virus (HIV) infection by inhibiting the enzyme reverse transcriptase, which prevents HIV from replicating its genome. Cyclopropanecarboxaldehyde also inhibits malonic acid decarboxylase, which prevents production of malonic acid and thus glucose by inhibiting glycolysis, leading to diabetic neuropathy. This compound also can cause kinetic energy changes due to its electron withdrawing effects on

Cyclopropanecarboxaldehyde

Stability Volatile Applications Cyclopropanecarboxaldehyde is a reagent in the preparation of N-alkylphenylalaninamides of pyridinylphenyl- and oxobipyridinylamines as human GPR 142 agonists for potential use as anti-diabetic agents and the cytochrome P 450 inhibition. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Lizarzaburu, M., et al.: Bioorg. Med. Chem. Lett, 22, 5942 (2012)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.