CAS 149022-16-2: Harmol hydrochloride dihydrate

Harmol hydrochloride dihydrate is a fine chemical that is used as a building block in the synthesis of more complex compounds.

Harmol hydrochloride dihydrate is a compound that has been classified as a group 1 carcinogen. It is used in functional assays to activate cells and induce genotoxic effects. Harmol hydrochloride dihydrate also has monolayer-enhancing properties, which have been observed in experiments using an electron microscope. Harmol hydrochloride dihydrate binds to the N-methyl-D-aspartate (NMDA) receptor, preventing the binding of the neurotransmitter glutamate and blocking NMDA-induced currents. This inhibition of NMDA receptors leads to impairment of learning and memory in humans. Harmol hydrochloride dihydrate also causes micronucleus formation in mice and enhances DNA damage caused by radiation or β-carboline alkaloids.

Harmol hydrochloride dihydrate is used to induces apoptosis by Caspase-8 activation, CNS stimulant, may act through NMDA receptors, and antitumor agent. Harmol has been shown to inhibit haspin kinase. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.