UNC2881, with the CAS number 1493764-08-1, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential applications in neuroscience. It is known as a selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which plays a crucial role in the metabolism of endocannabinoids. By inhibiting FAAH, UNC2881 may enhance the levels of endocannabinoids, potentially leading to therapeutic effects in conditions such as pain, anxiety, and inflammation. The compound is characterized by its specific binding affinity and selectivity, which are essential for minimizing off-target effects. Additionally, UNC2881 has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are critical for evaluating its viability as a drug candidate. Overall, UNC2881 represents a promising avenue for research in the modulation of the endocannabinoid system and its implications for various neurological disorders.

UNC2881

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UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.

Inhibits Mer receptor tyrosine kinase (IC50 = 4.3 nM). Selective over Axl (84-fold) and Tyro3 (58-fold). UNC 2881 inhibits phosphorylation of Mer kinase in 697 B-ALL cells (IC50 = 22nM). Inhibits EGF-induced activation of a chimeric enzyme, composed of EGFR fused with Mer. Blocks collagen-mediated platelet aggregation, implying the potential of this compound for treating thrombosis.

CAS 1493764-08-1: UNC2881

UNC2881

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UNC2881

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UNC 2881

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