CAS 149676-40-4: Pefloxacin

PEFLOXACIN MESILATE DIHYDRATE CRS

1-Ethyl-6-Fluoro-7-(4-Methylpiperazin-1-YL)-4-Oxo-Quinoline-3-Carboxylic Acid

A broad spectrum antibiotic that targets Gram-negative and -positive bacteria, and also some mycoplasma species This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Pefloxacin Mesylate Dihydrate (1589 RB) , an antibacterial agent, restrains bacterial DNA replication by inhibiting DNA gyrase (topoisomerase).

Pefloxacin Mesylate Dihydrate

Pefloxacin mesylate is a prodrug of pefloxacin that is hydrolyzed to the active form in vivo. Pefloxacin is an antibiotic that inhibits bacterial growth by interfering with DNA synthesis by binding to the bacterial ribosome, thereby blocking protein synthesis. This drug has been shown to be effective against gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus. However, it is not active against gram-negative bacteria such as Escherichia coli or Pseudomonas aeruginosa. Pefloxacin mesylate dihydrate can be administered intravenously at a low dose without any adverse effects on healthy adults. It has also been shown to inhibit the growth of antibiotic-resistant strains of many species, including methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium.

Applications Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.