1,1-Difluoromethanesulfonyl chloride, with the CAS number 1512-30-7, is a chemical compound characterized by its unique structure, which includes a sulfonyl chloride functional group and two fluorine atoms attached to a methylene carbon. This compound is typically a colorless to pale yellow liquid and is known for its reactivity, particularly as a sulfonylating agent in organic synthesis. It is highly polar due to the presence of electronegative fluorine atoms and the sulfonyl chloride group, which contributes to its ability to participate in nucleophilic substitution reactions. The compound is also sensitive to moisture and can hydrolyze in the presence of water, releasing hydrochloric acid and forming the corresponding sulfonic acid. Due to its reactivity, 1,1-difluoromethanesulfonyl chloride must be handled with care, as it can be corrosive and poses health hazards upon exposure. It finds applications in the synthesis of various fluorinated compounds and in the pharmaceutical industry for the development of new drugs.

1,1-Difluoromethanesulfonyl chloride

1512-30-7: 1,1-Difluoromethanesulfonyl chloride, Difluoromethanesulfonyl Chloride, Methanesulfonyl chloride, 1,1-difluoro-, Methanesulfonyl chloride, difluoro-, Difluoromethanesulphonyl chloride,  Methanesulfonylchloride, 1,1-difluoro-

Difluoromethanesulphonyl chloride

Stability Very Very Moisture Sensitive
Applications Difluoromethanesulfonyl Chloride is a reactant used in the synthesis of ketoconazole sulfonamide analogs as antifungal agents.
References Blass, B. et al.: Bioorg. Med Chem. Lett., 26, 5825 (2016);


CAS 1512-30-7: 1,1-Difluoromethanesulfonyl chloride

Difluoromethanesulphonyl chloride

Ref: 54-PC53298

Difluoromethanesulfonyl Chloride

Ref: TR-D447698

Difluoromethanesulfonyl chloride

Ref: 10-F097711