2-Chloro-5-nitronicotinic acid ethyl ester is a chemical compound characterized by its structural features, which include a chlorinated and nitro-substituted pyridine ring. The presence of the chloro group and the nitro group on the pyridine ring contributes to its reactivity and potential applications in organic synthesis and medicinal chemistry. As an ethyl ester, it possesses an ester functional group, which can influence its solubility and reactivity in various chemical reactions. This compound may exhibit biological activity, making it of interest in pharmaceutical research. Its CAS number, 151322-83-7, allows for precise identification and retrieval of information regarding its properties, safety data, and potential applications. Generally, compounds of this nature are studied for their roles in drug development, agrochemicals, or as intermediates in synthetic pathways. Proper handling and safety measures should be observed due to the presence of potentially hazardous functional groups.

2-CHLORO-5-NITRONICOTINIC ACID ETHYL ESTER

151322-83-7: Ethyl 2-chloro-5-nitronicotinate, Ethyl 2-Chloro-5-Nitropyridine-3-Carboxylate

Ethyl 2-chloro-5-nitronicotinate

3-Pyridinecarboxylic acid, 2-chloro-5-nitro-, ethyl ester

2-Chloro-5-nitronicotinic acid is a potent inhibitor of HIV-1 reverse transcriptase. It has been shown to inhibit the transcription of HIV-1 with an IC50 value of 0.3 μM, as well as other retroviruses in vitro. 2-Chloro-5-nitronicotinic acid binds reversibly to the active site of the enzyme and inhibits its activity. The binding site for this drug is located at the Y181C position, which is a mutation that renders the enzyme more sensitive to inhibition by 2-chloro-5 nitronicotinic acid than wild type HIV enzymes.

CAS 151322-83-7: 2-CHLORO-5-NITRONICOTINIC ACID ETHYL ESTER

Ethyl 2-chloro-5-nitronicotinate

Ref: 54-OR42164

Ethyl 2-chloro-5-nitronicotinate

Ref: 10-F223446

3-Pyridinecarboxylic acid, 2-chloro-5-nitro-, ethyl ester

Ref: IN-DA001NAB

2-Chloro-5-nitronicotinic acid

Ref: 3D-FC51033