CAS: 15148-92-2

De(2,3-dihydroxy) nadolol hydrochloride is a drug product that is custom synthesized to meet the needs of customers. The high purity and analytical quality of this drug makes it a good candidate for use in metabolism studies and drug development. De(2,3-dihydroxy) nadolol hydrochloride is a natural metabolite that has been found to be present in human urine as well as many other animal species. It is also an impurity standard for HPLC analysis. Metabolites of de(2,3-dihydroxy) nadolol hydrochloride have been identified in rat liver microsomes and these metabolites have been shown to inhibit the activity of the enzyme benzoate-CoA ligase (BCL), which is involved in the biosynthesis of cholesterol.

Applications De(2,3-dihydroxy) Nadolol Hydrochloride is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal. References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)