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CAS 15207-30-4: gramicidin S hydrochloride from*bacillus brevis (

Formula:C60H94Cl2N12O10
InChI:InChI=1/C60H92N12O10.2ClH/c1-35(2)31-43-53(75)67-45(33-39-19-11-9-12-20-39)59(81)71-29-17-25-47(71)55(77)70-50(38(7)8)58(80)64-42(24-16-28-62)52(74)66-44(32-36(3)4)54(76)68-46(34-40-21-13-10-14-22-40)60(82)72-30-18-26-48(72)56(78)69-49(37(5)6)57(79)63-41(23-15-27-61)51(73)65-43;;/h9-14,19-22,35-38,41-50H,15-18,23-34,61-62H2,1-8H3,(H,63,79)(H,64,80)(H,65,73)(H,66,74)(H,67,75)(H,68,76)(H,69,78)(H,70,77);2*1H/t41-,42-,43-,44-,45+,46+,47-,48-,49-,50-;;/m0../s1
Synonyms:
  • cyclo(L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl-L-valyl-L-ornithyl) dihydrochloride
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Found 2 products.
  • Gramicidin S 2HCl
    Targetmol
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    Gramicidin S 2HCl

    CAS:
    Gramicidin S 2HCl, is an antibiotic. At concentrations of 40-80 μg/mL, GS can reduce planktonic cell numbers within 20-40 minutes. For established biofilms, it effectively kills cells at concentrations of 100-200 μg/mL without regrowth. This anti-biofilm effect results from peptide transmembrane transport and complexation with intracellular nucleotides (including the alarmone ppGpp). GS demonstrates wide-ranging activity against biofilm-forming, drug-resistant infections caused by E. faecalis, proving its efficacy in endodontic treatment. The successful treatment of persistent infections in two volunteer cases further confirms GS's potent therapeutic performance. These studies indicate that GS can be applied in certifying compounds used in endodontics.
    Formula:C60H94Cl2N12O10
    Color and Shape:Solid
    Molecular weight:1214.37

    Ref: TM-T203753

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  • Gramicidin S hydrochloride
    Biosynth
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    Gramicidin S hydrochloride

    CAS:
    Gramicidin S hydrochloride is a cyclic peptide antibiotic, which is a derivative of the naturally occurring antibiotic gramicidin S. It is sourced from Bacillus brevis, a type of soil bacterium. This peptide operates through a unique mode of action, whereby it disrupts bacterial cell membranes. By integrating into the lipid bilayer, it increases membrane permeability, leading to leakage of essential ions and molecules, and ultimately causing cell death. Gramicidin S hydrochloride is primarily used in scientific research to study antibiotic mechanisms and membrane biology, given its potent ability to affect membrane integrity. Additionally, it holds potential for applications in developing novel antimicrobial agents, particularly in exploring resistance mechanisms and testing efficacy of new compounds. Its role in research is essential for advancing our understanding of peptide-based antimicrobial strategies, making it an invaluable tool in the fields of microbiology and pharmacology.
    Formula:C60H92N12O10•(HCl)2
    Purity:90%Min
    Molecular weight:1,214.37 g/mol

    Ref: 3D-FG168088

    1g
    2,754.00€
    500mg
    1,980.00€