CAS 1521-39-7: 2,3-Dimethoxybenzamide

2,3-Dimethoxybenzamide

2-Veratramide is a drug that belongs to the group of amides. It is a highly soluble, water-soluble and lipophilic molecule. The molecular modeling study revealed that it has a hydroxyl group in its structure and a hydrogen bond with the intramolecular hydrogen atom. 2-Veratramide has been observed to inhibit protein synthesis and cellular proliferation by binding to cancer cells or inflammatory cells. It also binds to dopamine receptors, inhibiting uptake of dopamine and subsequent activation of downstream signaling pathways. 2-Veratramide is an inhibitor of nitric oxide synthase (NOS), which plays an important role in inflammation, vascular tone, neurotransmission, and cell proliferation. 2-Veratramide inhibits NOS by competitively binding to the heme moiety at the active site of the enzyme, thereby blocking access to substrate arginine.