Sec-Butylmagnesium chloride, with the CAS number 15366-08-2, is an organomagnesium compound belonging to the class of Grignard reagents. It is characterized by its alkyl group, specifically the sec-butyl group, which contributes to its reactivity and utility in organic synthesis. This compound typically appears as a colorless to light yellow liquid or solid, depending on its form and purity. Sec-Butylmagnesium chloride is highly reactive, particularly with water and protic solvents, leading to the release of hydrocarbons and the formation of magnesium hydroxide. It is commonly used in the formation of carbon-carbon bonds, enabling the synthesis of various organic compounds, including alcohols, ketones, and other functional groups. Due to its reactivity, it must be handled under anhydrous conditions, often in an inert atmosphere, to prevent decomposition. Additionally, it is important to note that sec-butylmagnesium chloride is sensitive to air and moisture, necessitating careful storage and handling practices in a laboratory setting.

sec-Butylmagnesium chloride

15366-08-2: 2-Butylmagnesium chloride, Butan-2-Ylmagnesium(1+) Chloride, Chloro(1-methylpropyl)magnesium, Magnesium Chloride Butan-2-Ide (1:1:1), Magnesium, chloro(1-methylpropyl)-, Magnesium, sec-butylchloro-, sec-Butylchloromagnesium,  sec-Butylmagnesium chloride, sec-Butylmagnesium chloride

s-Butylmagnesium chloride 2M solution in THF

s-Butylmagnesium chloride 2M solution in DEE

sec-Butylmagnesium chloride is a synthetic organometallic compound with the general formula RMgCl. It is an important reagent in organic synthesis, used for reductive elimination and cross-coupling reactions. It can be prepared by the reaction of magnesium metal with sec-butyl bromide or by direct reaction of magnesium with butyllithium. The two isomers of sec-butylmagnesium chloride are distinguished by their staining properties: the less reactive isomer stains blue, while the more reactive isomer stains yellow.

It has been shown that exposure to sec-butylmagnesium chloride can cause symptoms such as aciduria and aryl chlorides, which may be due to its ability to reduce sulfhydryl groups and form mercaptans. Treatment for these symptoms include administration of sodium thiosulfate and methionine hydrochloride.

CAS 15366-08-2: sec-Butylmagnesium chloride

s-Butylmagnesium chloride 2M solution in THF

Ref: 54-OR320122

s-Butylmagnesium chloride 2M solution in DEE

Ref: 54-OR320123

sec-Butylmagnesium chloride, lithium chloride complex

Ref: 3D-QAA36608