CAS 154057-58-6: [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido

((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide is a useful organic compound for research related to life sciences. The catalog number is T66070 and the CAS number is 154057-58-6.

((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide

The target compound is a pharmaceutical intermediate, which is obtained by the reaction of cyclopropyl-4-fluorobenzene with 2-chloroquinoline. The intermediates are then dissolved in an organic solvent, such as toluene or xylene, and reacted with triphenylphosphine and hydrobromide. The resulting product can be purified by recrystallization or distillation.

Applications [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenyl-phosphonium Bromide is an impurity from the synthesis of HMG-CoA reductase inhibitor Pitavastatin [P531040, (Z)-Pitavastatin Calcium Salt]. References Takahashi, K., et al.: Tetrahdron Lett., 34, 8263 (1993); Takahashi, K., et al.: Bull. Chem. Soc. Japan, 68, 2649 (1995); Hiyama, T., et al.: Bull. Chem. Soc. Japan, 68, 364 (1995); Manne, S., et al.: Oriental J. Chem., 23, 559 (2007)