CAS: 154476-25-2

Heterocyclic compounds with nitrogen hetero-atom(s) only, aromatic or modified aromatic, nesoi

Descarboxy 1-hydroxy ketorolac is a drug that is used to relieve moderate to severe pain. It consists of tromethamine and 1-hydroxy ketorolac, a non-steroidal anti-inflammatory agent. The mechanism of action is due to the conversion of 1-hydroxy ketorolac into ketorolac trometamol, which inhibits prostaglandin synthesis by blocking cyclooxygenase. This drug has been shown to have a long term effect in doses ranging from 12.5 mg twice daily for two weeks to 100 mg twice daily for six months. Descarboxy 1-hydroxy ketorolac is soluble in water and can be administered by intramuscular injection or intravenously as an infusion over 15 minutes.

Impurity Ketorolac EP Impurity A; Ketorolac USP Related Compound B Applications Descarboxy 1-Hydroxy Ketorolac (Ketorolac EP Impurity A; Ketorolac USP Related Compound B) is an impurity of Ketorolac (K235650), an analgesic and anti-inflammatory agent. References Etman, M., et al.: Pharm. Technol., 32, 58 (2008), Chelladurai, S., et al.: Chem. Pharm. Bull., 56, 1596 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),