2',6'-Difluoroamodiaquine is a synthetic compound primarily recognized for its antimalarial properties. It is a derivative of amodiaquine, which is a 4-aminoquinoline. The presence of two fluorine atoms at the 2' and 6' positions of the aromatic ring significantly alters its pharmacological profile, enhancing its efficacy against malaria parasites. This compound exhibits a mechanism of action similar to that of chloroquine, primarily by interfering with the heme detoxification process in the malaria parasite. In terms of solubility, 2',6'-difluoroamodiaquine is generally more soluble in organic solvents than in water, which can influence its bioavailability and absorption in biological systems. The compound's chemical structure contributes to its stability and potential for modification, making it a subject of interest in medicinal chemistry for developing new antimalarial therapies. Additionally, its safety profile and potential side effects are important considerations in its therapeutic application, necessitating further research to optimize its use in clinical settings.

2',6'-difluoroamodiaquine

155020-40-9: 4-((7-Chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-3,6-difluorophenol, Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-3,6-difluoro-, 4-[(7-Chloroquinolin-4-Yl)Amino]-2-[(Diethylamino)Methyl]-3,6-Difluorophenol, 2',6'-Difluoroamodiaquine

4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Diethylaminomethyl)-3,6-Difluorophenol (CQA) is a potential antimalarial with a novel mechanism of action that has been shown to be effective in treating both chloroquine and pyrimethamine/sulfadoxine resistant strains of Plasmodium falciparum. CQA inhibits the synthesis of heme, which is necessary for the parasite's survival. The compound binds to the parasite's DNA and inhibits the incorporation of an essential sulphur atom into heme. This leads to inhibition of the parasite's growth and development. CQA also has been shown to inhibit the metabolism of cyclic nucleotides by inhibiting cyclic GMP phosphodiesterase activity in cultured cells.

CAS 155020-40-9: 2',6'-difluoroamodiaquine

4-[(7-Chloroquinolin-4-Yl)Amino]-2-(Diethylaminomethyl)-3,6-Difluorophenol

Ref: 3D-FC99668