CAS: 15599-45-8

Symetine(L 16726) is a small molecule compound with antiparasitic activity that can be used to study amoebic liver abscesses in guinea pigs.

Symetine is a synthetic peptide-based compound, which is a highly selective agonist of the adenosine A2A receptor. This receptor is coupled to G-proteins mainly associated with activating adenylate cyclase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels within the cell. Symetine binds with high affinity to these receptors, inducing a conformational change that facilitates the downstream signaling pathways associated with this receptor family. The primary applications of Symetine are in the fields of neurobiology and cardiovascular research, where it serves as a tool to probe the physiological and pathophysiological roles of the adenosine A2A receptor. By selectively activating this receptor, researchers can delineate its role in modulating neurotransmission, neuroprotection, and inflammation. Moreover, due to its influence on cAMP levels, Symetine is also utilized in research focused on metabolic regulation and cellular energy homeostasis. Understanding the action of Symetine and its receptor may provide insights into various medical conditions, including neurodegenerative diseases, ischemic injuries, and inflammatory disorders.