CAS 157327-43-0: 1,1-Dimethylethyl 3-acetyl-4-oxo-1-piperidinecarboxylate

Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate is a potent, selective, and orally active potassium channel blocker with high potency. It has been shown to have antidepressant and antiemetic effects in animal studies. Tert-butyl 3-acetyl-4-oxopiperidine-1-carboxylate binds to the Kv1.3 potassium channel, which is an important target for treating depression and nausea. It also blocks the 5HT6 serotonin receptor, which may contribute to its antidepressant activity. The drug is a linear tertiary amine that contains an intramolecular hydrogen bond between the acetylene oxygen and the nitrogen of the piperidine ring. This hydrogen bond stabilizes the molecule in a conformation that allows for potent binding to Kv1.3 channels.