Fmoc-D-His-OH, or 9-fluorenylmethoxycarbonyl-D-histidine, is a protected form of the amino acid D-histidine, commonly used in peptide synthesis. The Fmoc group serves as a protective moiety that allows for selective deprotection during the synthesis process. This compound is characterized by its ability to form stable peptide bonds, making it valuable in the construction of peptides and proteins. Fmoc-D-His-OH is typically a white to off-white solid and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dimethylformamide (DMF), but less soluble in water. Its structure includes a histidine side chain, which can participate in various biochemical interactions due to its imidazole group, contributing to the overall properties of the peptides it forms. The compound is widely utilized in research and pharmaceutical applications, particularly in the development of biologically active peptides. Proper handling and storage are essential, as with many chemical substances, to maintain its stability and efficacy.

Fmoc-D-His-OH

157355-79-8: N-Alpha-(9-Fluorenylmethoxycarbonyl)-D-Histidine, Fmoc-D-Histidine

D-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Fmoc-D-His

N-alpha-Fmoc-D-histidine is a reagent that can be used to solubilize organic compounds in water. It is soluble in a variety of organic solvents, including glycol ethers, and has been shown to have catalytic properties. N-alpha-Fmoc-D-histidine has also been used as a moiety in the synthesis of peptides and proteins. The c-terminal amino acid group is detectable by TLC or HPLC, depending on the solvent system used. This reagent can be synthesized with high yield and it is water soluble.

N-α-Fmoc-D-histidine

Applications Nα-Fmoc-D-histidine is an N-Fmoc-protected form of D-Histidine (H456015). D-Histidine is the unnatural, biologically inactive isomer of L-Histidine (H456010). D-histidine is known to inhibit cell division, and is also used by certain types of bacteria (such as Escherichia coli) as a source of L-Histidine.
References Aiken, S., et al.: J. Phys., 445, 69 (1992); Caldara, M., et al.: J. Mol. Bio., 373, 251 (2007); Grula, E. & Grula, M.: Biochim. Biophys. Acta, 74, 776 (1963)


CAS 157355-79-8: Fmoc-D-His-OH

D-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

Ref: IN-DA001PE4

Fmoc-D-His

Ref: 10-F222160

N-α-Fmoc-D-histidine

Ref: 3D-FF48571

NAlpha-Fmoc-D-histidine

Ref: TR-F633005