CAS: 158636-96-5

(S)-Isotimolol is a ligand for the beta-adrenergic receptor that has been used as a research tool in cell biology and pharmacology. It is an inhibitor of ion channels. (S)-Isotimolol may also be used as a diagnostic aid for determining the presence of peptides or receptors on cells. (S)-Isotimolol is soluble in DMSO, ethanol, and acetone, with a solubility of 1 g/100 mL at 25°C. It is stable to hydrolysis by esterases and other enzymes. It has been shown to activate the beta-adrenergic receptor at micromolar concentrations. This results in increased calcium influx into the cell, activation of protein kinase A, and increased cyclic adenosine monophosphate (cAMP) levels. (S)-Isotimolol binds to the alpha-1A subtype of the beta-ad

Applications An isomer of the antiarrhythmic, antiglaucoma agent Timolol (T443700). References Marini, R.D. et al.: Anal. Chim. Acta, 531, 131 (2005);