Ac-Nle-OH, also known as Acetyl-Norleucine, is a chemical compound characterized by its acetylated amino acid structure. It features an acetyl group attached to the nitrogen of the amino group, which enhances its stability and solubility in various solvents. The presence of the norleucine side chain contributes to its unique properties, making it relevant in peptide synthesis and biochemical research. Ac-Nle-OH is typically utilized in the study of protein interactions and as a building block in the synthesis of peptides due to its ability to mimic natural amino acids while providing distinct functional characteristics. Its CAS number, 15891-49-3, allows for easy identification in chemical databases. The compound is generally stable under standard laboratory conditions but should be handled with care, as with all chemical substances, to avoid potential hazards. Overall, Ac-Nle-OH serves as a valuable tool in the fields of biochemistry and medicinal chemistry, facilitating the exploration of peptide-based therapeutics and biological processes.

Ac-Nle-OH

15891-49-3: N-Acetyl-L-2-Amino-Caproic Acid, N-Acetyl-L-Norleucine, Ac-L-Nhch[Ch3(Ch2)3]-Cooh, Ac-Ahx(2)-Oh, Ac-Acpo(2)-Oh, Acetyl-L-Norleucine, Acetyl-L-2-Aminohexanoic Acid

(S)-2-Acetamidohexanoic acid

Acetyl-L-norleucine is a synthetic amino acid that has been shown to inhibit the growth of cancer cells in vitro. It forms an amphipathic molecule that has hydrophobic and hydrophilic regions, which may allow it to attach to the cell membrane of a tumor cell. Acetyl-L-norleucine binds to both the active site and the allosteric site on acylase, inhibiting its activity. This inhibition prevents the breakdown of formylglycinamide into formate and glycinamide, which are required for fatty acid synthesis.

CAS 15891-49-3: Ac-Nle-OH

(S)-2-Acetamidohexanoic acid

Ref: 10-F235602

Acetyl-L-norleucine

Ref: 3D-FA49081

L-Norleucine, N-acetyl-

Ref: IN-DA001R0S

(2S)-2-Acetamidohexanoic acid

Ref: 54-OR963188