CAS 158959-32-1: Benzene,1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-

SC57666 is an inhibitor of the transport of cholesterol into cells. It has been shown to be effective in treating hepatitis and polycystic ovarian syndrome. The mechanism of action of SC57666 is not known, but it may work by inhibiting the production of Cox-2 and decreasing the production of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α. SC57666 also inhibits hyperproliferative diseases such as cancer by preventing oxidative phosphorylation. SC57666 has also shown to have anti-inflammatory activity through its inhibitory effect on serotonin reuptake and cholinergic transmission.

SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.

SC57666