CAS 15942-08-2: trans-4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)yl)cyclohexanol

Impurity Ambroxol EP Impurity B Hydrochloride Stability Hygroscopic Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900). References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC & CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);

Ambroxol hydrochloride impurity B is a byproduct of the chemical synthesis of Ambroxol hydrochloride. It is an organic compound that is a colorless, crystalline solid with a melting point of 93°C and a vapor pressure of 0.0012 mmHg at 25°C. The biological relevance and chronic bronchitis detection time of Ambroxol hydrochloride impurity B are unknown. Chemical reactions involving this compound include hydrolysis, oxidation, esterification, and reduction. Ambroxol hydrochloride impurity B has been detected in human blood plasma as well as in the lungs, liver, spleen, brain and kidney tissues following intravenous administration. This substance can be found as a metabolite in urine and feces following oral ingestion or injection.