CAS 1601-18-9: Methyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

Indomethacin methyl ester is a nonsteroidal anti-inflammatory drug. It inhibits the biosynthesis of prostaglandins, which are hormones that cause inflammation and pain. Indomethacin methyl ester has been shown to be effective in treating inflammatory diseases such as asthma, arthritis, and bursitis. The drug is an amide with two functional groups: an ethyl ester and a hydroxyl group. The medication is metabolized into indomethacin by hydrolysis of the ester bond and demethylation of the hydroxyl group. The drug binds to particle surfaces by hydrogen bonding interactions and does not penetrate cell membranes well. This may explain why it has a lower effective dose than other NSAIDs such as ibuprofen or naproxen sodium. Indomethacin methyl ester can also be administered orally or intravenously at high doses for severe cases of inflammation or pain.

Applications Selective COX-2 inhibitor Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Kulmacz, R.J., et al.: J. Biol. Chem., 264, 14136 (1989), Kalgutkar, A.S., et al.: J. Med. Chem., 43, 2860 (2000), Hata, A.N., et al.: Mol. Pharmacol., 67, 640 (2005), Tuccinardi, T., et al.: J. Med. Chem., 49, 984 (2006),