CAS: 1603845-32-4

TX1-85-1

TX1-85-1: irreversible Her3 inhibitor (IC50: 23 nM), degrades Her3 protein, disrupts signaling, binds Cys721 covalently.

TX 1-85-1 is a small molecule that inhibits the ubiquitin-proteasome system and blocks the growth factor signal pathway. It can be used as a cancer therapy for cancer cells, including those of the epidermis. This drug has been shown to induce cellular proliferation in human epidermal keratinocytes, which may be due to its ability to activate epidermal growth factor receptors on these cells. TX 1-85-1 also blocks receptor tyrosine kinases and normalizes the function of the epidermal growth factor receptor.