CAS 1608-26-0: Tris(dimethylamino)phosphine

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Hexamethylphosphorous triamide (HMT) is an activator that is used in pharmaceutical preparations. It is a white, water-soluble powder that reacts with carbonyl groups to form nitriles. Nitriles are useful intermediates in organic synthesis reactions because they are readily convertible to carboxylic acids, amides, and esters. HMT has been shown to be effective in the treatment of inflammatory diseases such as rheumatoid arthritis and psoriasis by inhibiting the production of prostaglandins and leukotrienes. HMT also binds to DNA polymerase and inhibits RNA synthesis. The reaction mechanism starts with the addition of a halide substrate or diphenyl ether to the activated complex of HMT. This causes a rearrangement of the phosphorous center and formation of an alkanoic acid product with an N-H group on one end and a carbonyl group at the other end. The transfer reactions occur

Tris(dimethylamino)phosphine

Tris(dimethylamino)phosphine, min. 98% HMPT

Hexamethylphosphorous triamide is used as a reagent in organic synthesis as a phosphorylating agent. It is associated with carbon tetrachloride for the substitution of hydroxy groups with chlorides. It is involved in the preparation of epoxides and arene oxides from aldehydes and aryldialdehdyes respectively. It is used in the preparation of carbonates as well as reduction of ozonides. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.