CAS: 160970-86-5

O-Acetyl silodosin is a synthetic, natural metabolite of silodosin. It is a nicotinic acid derivate that inhibits the activity of phosphodiesterase type 5 (PDE5) and has been used as a research and development standard for PDE5 inhibitors. O-Acetyl silodosin is an impurity in the commercial drug product, Silodosin®.

Applications O-Acetyl Silodosin is an impurity of Silodosin (S465000); an α1a-adrenoceptor antagonist. Also used in the treatment of benign prostatic hypertrophy. References Shibata, K., et al.: Mol. Pharmacol., 48, 250 (1995); Murata, S., et al.: J. Urol., 164, 578 (2000)