CAS: 161552-03-0

Cyclo(-RGDfK)

Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a synthetic peptide that binds to the integrin receptor on pancreatic cancer cells. It has been shown to be an effective diagnostic tool for pancreatic cancer and other cancers, such as prostate, breast, and lung. Cyclo(Arg-Gly-Asp-D-Phe-Lys) selectively binds to cells with high levels of integrin receptors by using "a heterofunctional approach." This technique is used in the synthesis of peptides because it increases the stability of peptides. Cyclo(Arg-Gly-Asp-D-Phe-Lys) can be used for diagnosis or therapeutic purposes.

Cyclo(-RGDfK) is a selective and potent inhibitor of integrin αvβ3 with an IC50 value of 0.94 nM.Cost-effective and quality-assured.

Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a small molecule drug that binds to the integrin receptor and blocks the growth of solid tumours. It has been shown to inhibit angiogenesis, especially in choroidal neovascularization in mice. Cyclo(Arg-Gly-Asp-D-Phe-Lys) is a cyclic peptide with biological properties that are similar to those of the natural amino acids found in protein. This drug has been shown to be safe for use in humans and animals, with no observed toxicity or side effects.

An RGD tumor-targeting peptide, which binds to αvβ3 receptors. c(RGDfK) can be easily conjugated to fluorophore tags, chelators, or carriers. Palecek et al. converted the ε-amino group into the azide by diazo transfer allowing further functionalization by click chemistry. Mercapto groups can be introduced via acylation of c(RGDfK) with S-acetylthioacetic acid (SATA).

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Applications Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA. References Liu, L. et al.: Int. J. Nanomed., 9, 3509 (2014);