CAS: 1616287-82-1

PF-06726304

PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).

PF-06726304 is a novel small molecule that has been shown to inhibit prostate cancer growth in preclinical models. PF-06726304 binds to an antigen on the surface of prostate cells and induces apoptosis through a number of mechanisms, including radical prostatectomy, primary tumor growth, and resistant cancer. This agent also inhibits the proliferation of cancer stem cells and shows systemic effects on primary tumors. PF-06726304 acetate also blocks protein-protein interactions that are involved in cell survival pathways and may be effective in treating cancers such as breast cancer.