CAS 161796-77-6: 1H-Benzimidazole, 6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-, sodium salt (1:1)

Applications R-Form of Omeprazole. Gastric proton-pump inhibitor. References Stenhoff, H., et al.: J. Chromatogr., 734, 191 (1999), Johnson, D.A., et al.: Expert Opin. Pharmacother., 4, 253 (2003),

Omeprazole is a drug that belongs to the class of proton pump inhibitors and is used for the treatment of stomach ulcers, gastroesophageal reflux disease, and other conditions. Omeprazole has been shown to inhibit the growth of Helicobacter pylori in vitro. Omeprazole also inhibits bacterial enzyme activity by binding to the active site of a bacterial enzyme, such as esomeprazole. The inhibition of these enzymes leads to a decrease in bacterial cell division and an increase in cell death. In addition, omeprazole can inhibit the growth of bacteria that are sensitive to antibiotics. Omeprazole has been shown to have anti-inflammatory properties, which may be due to its inhibition of prostaglandin synthesis.

(R)-Omeprazole, inactive omeprazole isomer, inhibits CYP2C19; IC50=8.1μM in human liver microsomes.

Compounds containing an unfused pyridine ring in the structure, nesoi