UNC0379, with the CAS number 1620401-82-2, is a small molecule that functions primarily as a selective inhibitor of the protein lysine-specific demethylase 1 (LSD1). This compound is notable for its role in epigenetic regulation, particularly in the context of gene expression modulation. UNC0379 exhibits a high degree of specificity for LSD1, making it a valuable tool in research focused on cancer biology and other diseases where epigenetic modifications play a critical role. The compound's mechanism of action involves the inhibition of demethylation processes, which can lead to altered transcriptional activity of target genes. In addition to its biochemical properties, UNC0379 has been studied for its potential therapeutic applications, particularly in hematological malignancies and solid tumors. Its development reflects a growing interest in targeting epigenetic enzymes as a strategy for cancer treatment. As with many experimental compounds, further research is necessary to fully understand its pharmacokinetics, toxicity, and therapeutic efficacy in clinical settings.

UNC0379

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UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

Inhibitor of the histone methyltransferase SETD8 that supresses methylation of the K20 residue in histone 4. UNC 0379 treatment of human glioma reduced recruitment of 53BP1 protein to double strand breaks and sensitised cells to radiotherapy without altering cell cycle kinetics.

CAS 1620401-82-2: UNC0379

UNC0379

Ref: TM-T1841

4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-

Ref: IN-DA001SNW

UNC0379

Ref: 54-BUP06060

UNC 0379

Ref: 3D-FU137732