CAS: 1621326-32-6

para-Nitroblebbistatin

para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II.Cost-effective and quality-assured.

p-Nitroblebbistatin is a photostable small-molecule inhibitor, which is derived from the original compound blebbistatin. It acts specifically on non-muscle myosin II ATPase, inhibiting its activity without affecting other myosin isoforms or closely related ATPases. This compound is synthesized through chemical modification of blebbistatin, incorporating a nitro group to enhance its stability under light exposure. The mode of action involves binding to the motor domain of myosin II, preventing force generation and disrupting cellular processes like cytokinesis, cell motility, and muscle contraction. p-Nitroblebbistatin’s applications are significant in cellular and molecular biology where it is used to study actin-myosin interactions and dynamics in various contexts. Due to its non-phototoxic nature, it is particularly useful in live-cell imaging and prolonged experimental conditions where traditional blebbistatin would degrade rapidly. Researchers leverage this compound to investigate myosin-related cellular functions, providing insights into mechanisms of cell movement, morphological changes, and mechanical properties. Such exploration is crucial for advancing understanding in fields like cancer research, developmental biology, and tissue engineering.