CAS 1623101-11-0: 2-Chloro-N-[3-chloro-4-(4-chloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-phenyl]-nicotinamide

VU0483605

VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.

VU 0483605 is a selective allosteric modulator, which is a type of small molecule compound. It originates from the field of neuropharmacology research, specifically designed to interact with metabotropic glutamate receptors (mGluRs), a class of G-protein-coupled receptors. This compound exhibits a selective mode of action by targeting mGlu receptor subtypes with high affinity, modulating their physiological and pathophysiological roles in the central nervous system. The primary use of VU 0483605 is in research settings, where it serves as a valuable tool for studying the nuances of glutamate signaling pathways. By modulating receptor activity, researchers can explore the compound's effects on synaptic transmission, plasticity, and neuroprotection, thereby gaining insights into mechanisms involved in various neurological disorders. These investigations are pivotal for understanding diseases such as schizophrenia, anxiety, and epilepsy, where glutamate signaling is often dysregulated. Through its precise action, VU 0483605 helps elucidate potential therapeutic targets, advancing the field of neuroscience and aiding in the development of novel interventions.