4-Chloro-1-methyl-1H-indazole is a chemical compound characterized by its indazole core, which is a bicyclic structure containing a five-membered ring fused to a six-membered ring. The presence of a chlorine atom at the 4-position and a methyl group at the 1-position contributes to its unique chemical properties. This compound is typically a solid at room temperature and is known for its potential applications in medicinal chemistry, particularly in the development of pharmaceuticals. It may exhibit biological activity, including effects on various biological pathways, making it of interest in research. The molecular structure allows for various interactions, including hydrogen bonding and hydrophobic interactions, which can influence its solubility and reactivity. Additionally, the compound's stability and reactivity can be affected by the presence of the chlorine substituent, which can participate in electrophilic aromatic substitution reactions. Overall, 4-chloro-1-methyl-1H-indazole is a compound of interest in both synthetic and medicinal chemistry contexts.

4-chloro-1-methyl-1H-indazole

162502-53-6: 1H-indazole, 4-chloro-1-methyl-,  4-Chloro-1-methyl-1H-indazole

4-Chloro-1-methyl-1H-indazole

4-Chloro-1-methyl-1H-indazole is an antagonist of the TRPV1 receptor. It is a benzyl derivative that has been shown to be a potent and selective antagonist of the TRPV1 receptor in vitro. 4-Chloro-1-methyl-1H-indazole binds to the TRPV1 receptor with high affinity and inhibits its activity. This leads to a decrease in the release of proinflammatory cytokines, such as IL6, TNFα, and IL8. 4-Chloro-1-methyl-1H-indazole also suppresses inflammation by inhibiting the production of reactive oxygen species (ROS) and nitric oxide (NO).

CAS 162502-53-6: 4-chloro-1-methyl-1H-indazole

4-Chloro-1-methyl-1H-indazole

Ref: 10-F067657

4-Chloro-1-methyl-1H-indazole

Ref: 54-OR2244

4-Chloro-1-methyl-1H-indazole

Ref: 3D-MGA50253

1H-Indazole, 4-chloro-1-methyl-

Ref: IN-DA001T7C