CAS: 1627503-67-6

LDN 214117 is a small molecule that has been shown to inhibit the activity of a variety of receptors including G protein-coupled receptors, tyrosine kinase receptors, and chemokine receptors. LDN 214117 binds to the ligand binding site of these receptors and blocks signal transduction. LDN 214117 is not active against mesenchymal stem cells or epidermal growth factor receptor (EGFR) expressing cancer cells, which may be due to its low expression in these cells. This drug has also been shown to have pharmacokinetic properties that allow for oral administration.

LDN-214117

LDN-214117 is a potent and selective ALK2 inhibitor.