CAS: 1627902-21-9

JNJ-54175446

JNJ-54175446 is a novel antidepressant drug that has a high uptake in the brain. It is an investigational drug that has been shown to have a rapid onset of action and to be effective across multiple depression symptom domains, including mood, anxiety, and cognitive symptoms. JNJ-54175446 binds to the serotonin transporter (SERT) with higher affinity than other antidepressants, which may contribute to its rapid onset of action. The compound also penetrates the blood-brain barrier more easily than other antidepressants and does not show signs of tolerance or withdrawal when used for up to 12 weeks. Clinical studies have shown that JNJ-54175446 has pharmacokinetic properties suitable for once-daily administration. In addition, this drug has been shown to increase levels of brain-derived neurotrophic factor (BDNF) in rats and mice, as well as microglia cells in animal models. This suggests that JNJ-54175446 may have beneficial effects on the brain's microenvironment

JNJ-54175446 (JNJ-5446) is a P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia and is used in the study of depression.