CAS 1632032-53-1: 3-[(4-Methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Applications LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model. References Hong, C. S., et al.: Cancer Biol. Ther., 16, 821 (2015)

LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.

LB100

LB-100 is a cell-specific drug that has been shown to inhibit the growth of cancer cells in vitro. This drug has also been shown to have an antitumor response against bowel disease and inflammatory bowel disease, as well as an anti-inflammatory effect. LB-100 is a dinucleotide phosphate that has been activated by radiation, which increases its potency. The activation of LB-100 may be due to its ability to bind to nucleic acids and inhibit the synthesis of DNA or RNA. It has also been shown to have a pharmacological effect on meningioma and cervical cancer cells in vitro. LB-100 is a low potency drug that inhibits the synthesis of DNA or RNA by binding to nucleic acids, but does not induce apoptosis or necrosis.

(Rac)-LB-100 is the racemic form of the compound LB-100, which functions as an inhibitor of protein phosphatase 2A (PP2A) [1].