Fmoc-p-azido-Phe-OH, with the CAS number 163217-43-4, is a chemical compound commonly used in peptide synthesis and bioconjugation applications. It features a phenylalanine (Phe) residue modified with an azido group, which is a functional group containing three nitrogen atoms (N3) that is highly reactive and useful for click chemistry. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protecting group for the amino functionality, allowing for selective reactions during peptide synthesis. This compound is typically solid at room temperature and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane. Its azido group enables the formation of stable linkages with various biomolecules, making it valuable in the development of targeted therapeutics and in the study of protein interactions. Safety precautions should be observed when handling this compound, as azides can be hazardous under certain conditions. Overall, Fmoc-p-azido-Phe-OH is a versatile building block in the field of organic and medicinal chemistry.

Fmoc-p-azido-Phe-OH

163217-43-4: Fmoc-Phe(4-N)-OH, Fmoc-p-azido-L-phenylalanine, Fmoc-L-4-azidophenylalanine,  Fmoc-Phe(4-N3)-OH

1-{4-[(2S)-2-carboxy-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]phenyl}triaz-2-yn-2-ium-1-ide

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Fmoc-4-azido-L-phenylalanine

FMOC-4-AZIDO-L-PHENYLALANINE

The azido group is sensitive towards piperidine. In Fmoc-SPPS, this derivative is best introduced as N-terminus or modified before elongating the peptide. Fmoc-p-azidophenylalanine may be inserted as a precursor of p-aminophenylalanine. Levinson et al. reduced the azido group on-resin with a large excess of tributylphosphine in DMF.

CAS 163217-43-4: Fmoc-p-azido-Phe-OH

Fmoc-p-azido-Phe-OH

Ref: 54-OR36396

1-{4-[(2S)-2-carboxy-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]phenyl}triaz-2-yn-2-ium-1-ide

Ref: 10-F618997

Fmoc-4-azido-L-phenylalanine

Ref: 3D-FF48605

FMOC-4-AZIDO-L-PHENYLALANINE

Ref: IN-DA00ACR6

Fmoc-p-azido-Phe-OH

Ref: 01-4020251