CAS: 163958-73-4

TAPI-0 is a novel anti-inflammatory drug that binds to calmodulin and prevents the activation of protein kinase C. This compound inhibits many inflammatory mediators, including prostaglandin E2, cytokines and nitric oxide. Tapi-0 has been shown to be effective in decreasing the expression of chemokines such as MCP-1, MIP-1α, MIP-1β, RANTES and eotaxin in models of inflammation. TAPI-0 also inhibits the growth of cancerous cells by inhibiting transcriptional regulation. The mechanism by which TAPI-0 inhibits transcriptional regulation is not yet well understood but may involve inhibition of DNA polymerase activity.

ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.