CAS 16409-43-1: Rose oxide

4-Methyl-2-(2-methylpropenyl)tetrahydro-2H-pyran is a reaction product of glycol ethers and citronellol. It is used in the synthesis of terpenes and has been shown to inhibit the growth of bacteria by binding to bacterial dna gyrase and topoisomerase IV, which maintain the integrity of bacterial DNA. This compound has also been shown to have pharmacokinetic properties that depend on its route of administration. 4-Methyl-2-(2-methylpropenyl)tetrahydro-2H-pyran is metabolized by recombinant cytochrome P450 enzymes, such as CYP3A4. The metabolic products are oxidized by hydrogen fluoride or malonic acid, leading to an asymmetric synthesis that produces an oxide. The oxidation products are then excreted in urine as oxalate or glycine conjugates. Fatty

4-Methyl-2-(2-methylpropenyl)tetrahydro-2H-pyran