CAS: 1644069-80-6

DDR Inhibitor

DDR inhibitors are a class of drugs that inhibit the DDR, or DNA damage response. These drugs are used for the treatment of cancer and are thought to work by inhibiting cellular regulatory pathways. Studies have shown that these inhibitors can damage cells and prevent them from repairing damage caused by radiation or other damaging agents. One such inhibitor is olaparib, which has been found to be effective in the treatment of prostate cancer and some types of cancer that are resistant to traditional chemotherapy. It also reduces telomere length, which is associated with aging and cancer. The discovery of DDR inhibitors has provided the opportunity to develop more specific treatments for various cancers.

DDR inhibitor is a potent discidin domain receptor (DDR) inhibitor. The IC50 of DDR2 is 3.3 nM, and DDR1 has 53% inhibition at 1.5 nM.