CAS: 1644461-85-7

Ticagrelor sulfoxide is an oxidation product of ticagrelor, a drug that is used for the prevention and treatment of acute coronary syndrome (ACS). Ticagrelor sulfoxide has been found to be more effective in catalytic oxidation reactions than other chiral sulfoxides, such as difluorophenylsulfoxide. The optimal condition for this reaction is a temperature range of 150-200 degrees Celsius. This reaction sequence is useful for research purposes, because it provides a high yield and can be done without the use of hazardous reagents.

Applications Ticagrelor Sulfoxide is an impurity of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS). References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),