CAS 1647-26-3: 2-Cyclohexylethyl bromide

(2-Bromoethyl)cyclohexane

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Bromoethylcyclohexane (2BC) is a heterocycle that has shown antituberculosis activity. This compound inhibits the growth of mycobacteria by inhibiting protein synthesis and cell division, which are vital for bacterial growth. 2BC also has an inhibitory effect on the human papillomavirus (HPV). It binds to the virus' receptor, thereby preventing it from binding to a host cell. 2BC has been shown to be effective against skin cancer cells by inhibiting their proliferation. This heterocyclic compound has fluorescence resonance energy transfer properties and can be used as a marker for DNA double strand breaks in cells.

Applications 1-Bromo-2-cyclohexylethane is a reagent used in the cross-coupling and Grignard reactions. It is used in the synthesis of immunosuppressive agents consisting of 5-phenylalkoxypsoralens as well as agonists for human vitamin-D resistant Rickets. References Swann, S. et al.: J. Am. Chem. Soc., 124, 13795 (2002); Vennekamp, J. et al.: Mol. Pharm., 65, 1364 (2004); Bedford, R. et al.: Chem. Comm., 24, 2822 (2004); Lee, J. et al.: J. Am. Chem. Soc., 125, 5616 (2003);